c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter
IL-2 gene transcription occurs in an activation-dependent manner in T cells responding to TCR and CD28 activation. One of the critical events leading to increased IL-2 transcription is an alteration in chromatin structure across the 300-bp promoter region of the gene. We initially showed that IL-2 gene transcription in CD4+ primary T cells is dependent on the NF-κB family member, c-Rel, but not RelA. We found that c-Rel is essential for global changes in chromatin structure across the 300-bp...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Immunology|
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