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c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

Rao, Sudha; Gerondakis, Steve; Woltring, Donna; Shannon, M Frances


IL-2 gene transcription occurs in an activation-dependent manner in T cells responding to TCR and CD28 activation. One of the critical events leading to increased IL-2 transcription is an alteration in chromatin structure across the 300-bp promoter region of the gene. We initially showed that IL-2 gene transcription in CD4+ primary T cells is dependent on the NF-κB family member, c-Rel, but not RelA. We found that c-Rel is essential for global changes in chromatin structure across the 300-bp...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Immunology


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