Physics of Ion Channels
Date
2003
Authors
Kuyucak, Serdar
Bastug, Turgut
Journal Title
Journal ISSN
Volume Title
Publisher
Kluwer Academic Publishers
Abstract
We review the basic physics involved in transport of ions across membrane channels in cells. Electrochemical forces that control the diffusion of ions are discussed both from microscopic and macroscopic perspectives. A case is made for use of Brownian dynamics as the minimal phenomenological model that provides a bridge between experiments and more fundamental theoretical approaches. Application of Brownian and molecular dynamics methods to channels with known molecular structures is discussed.
Description
Keywords
Keywords: antibiotic agent; calcium; calcium channel; gramicidin A; ion channel; potassium; potassium channel; sodium ion; binding site; cell membrane permeability; chemical structure; conductance; conference paper; crystal structure; electrochemistry; ion transpor Brownian dynamics; Continuum theories; Ion channels; Molecular dynamics; Permeation models
Citation
Collections
Source
Journal of Biological Physics
Type
Journal article