Skip navigation
Skip navigation

Photoreceptor degeneration and loss of retinal function in the C57BL/6-C(2J) mouse

Bravo-Nuevo, A; Walsh, Natalie; Stone, Jonathan

Description

PURPOSE. The C57BL/6-c2J (c2J) mouse strain has been shown in earlier studies to be highly resistant to light damage. Subsequent studies related this resistance to an amino acid substitution (leu450met) in a pigment epithelial enzyme (RPE65), which slowed the rate of rhodopsin regeneration. The present study was conducted to examine patterns of photoreceptor death, electrophysiological function (the ERG) and trophic factor expression over the life of the C57BL/6-c2J retina. METHODS....[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/87612
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.03-0842

Download

There are no files associated with this item.


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator