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Synthesis, Electrochemistry, and Bioactivity of the Cyanobacterial Calothrixins and Related Quinones

Bernardo, Paul; Chai, Christina; Heath, Graham; Mahon, Peter; Smith, Geoffrey D; Waring, Paul; Wilkes, Bronwyn


The calothrixins are quinone-based natural products isolated from Calothrix cyanobacteria which show potent antiproliferative properties against several cancer cell lines. Preliminary mechanistic studies suggest that the biological mode of action of the calothrixins maybe linked to their ability to undergo redox cycling. In this study we compare the bioactivities of the calothrixins with those of structurally related quinones in order to identify the structural features in the calothrixins...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/jm049625o


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