Eosinophil degranulation in the allergic lung of mice primarily occurs in the airway lumen
Clark, Kristopher; Simson, Ljubov; Newcombe, Nicole; Koskinen, Aulikki; Lee, Nicola J; Lee, James L; Dent, Lindsay; Matthaei, Klaus; Foster, Paul S
Eosinophil degranulation is thought to play a pivotal role in the pathogenesis of allergic disorders. Although mouse models of allergic disorders have been used extensively to identify the contribution of eosinophils to disease, ultrastructural evidence of active granule disassembly has not been reported. In this investigation, we characterized the degree of eosinophil activation in the bone marrow, blood, lung tissue, and airways lumen [bronchoalveolar lavage fluid (BALF)] of...[Show more]
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|Source:||Journal of Leukocyte Biology|
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