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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kB signalling

Wen, S; O'Rourke, Karen; Zhou, Honglin; Eby, Michael; Aravind, L; Seshagiri, Somasekar; Wu, Ping-Shi; Wiesmann, Christian; Baker, Rohan; Boone, David; Ma, Averil; Koonin, Eugene; Dixit, Vishva

Description

NF-κB transcription factors mediate the effects of pro-inflammatory cytokines such as tumour necrosis factor-α and interleukin-1β. Failure to downregulate NF-κB transcriptional activity results in chronic inflammation and cell death, as observed in A2

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/86318
Source: Nature
DOI: 10.1038/nature02794

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