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The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-kB-Dependent c-myc Expression

Grumont, Raelene; Lock, Peter; Shannon, M Frances; Moore, Anna; Gerondakis, Steve; Mollinari, Michael

Description

Cell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-κB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires

dc.contributor.authorGrumont, Raelene
dc.contributor.authorLock, Peter
dc.contributor.authorShannon, M Frances
dc.contributor.authorMoore, Anna
dc.contributor.authorGerondakis, Steve
dc.contributor.authorMollinari, Michael
dc.date.accessioned2015-12-13T23:06:17Z
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/1885/85970
dc.description.abstractCell growth during the G1 stage of the cell cycle is partly controlled by inducing c-myc expression, which in B cells is regulated by the NF-κB1 and c-Rel transcription factors. Here, we show that c-myc-dependent growth during T cell activation requires
dc.publisherCell Press
dc.sourceImmunity
dc.subjectKeywords: protein kinase C theta; transcription factor Rel; article; cell cycle G1 phase; cell size; gene expression; genetic transcription; nuclear import; oncogene c myc; priority journal; T lymphocyte; T lymphocyte activation; Animals; Cell Size; DNA-Binding Pro
dc.titleThe Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-kB-Dependent c-myc Expression
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume21
dc.date.issued2004
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub14673
local.type.statusPublished Version
local.contributor.affiliationGrumont, Raelene, Walter and Eliza Hall Institute of Medical Research
local.contributor.affiliationLock, Peter, University of Melbourne
local.contributor.affiliationShannon, M Frances, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMoore, Anna, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGerondakis, Steve, Walter and Eliza Hall Institute of Medical Research
local.contributor.affiliationMollinari, Michael, Walter and Eliza Hall Institute of Medical Research
local.description.embargo2037-12-31
local.bibliographicCitation.startpage19
local.bibliographicCitation.lastpage30
local.identifier.doi10.1016/j.immuni.2004.06.004
dc.date.updated2015-12-12T08:04:36Z
local.identifier.scopusID2-s2.0-3142696783
CollectionsANU Research Publications

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