Calesquestrin and the calcium release channel of skeletal and cardiac muscle
Calsequestrin is by far the most abundant Ca2+-binding protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It allows the Ca2+ required for contraction to be stored at total concentrations of up to 20mM, while the free Ca2+ concentration remains at ∼1mM. This storage capacity confers upon muscle the ability to contract frequently with minimal run-down in tension. Calsequestrin is highly acidic, containing up to 50 Ca2+-binding sites, which are formed simply by clustering...[Show more]
|Collections||ANU Research Publications|
|Source:||Progress in Biophysics and Molecular Biology|
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