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Calesquestrin and the calcium release channel of skeletal and cardiac muscle

Beard, Nicole; Laver, Derek Rowland; Dulhunty, Angela


Calsequestrin is by far the most abundant Ca2+-binding protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It allows the Ca2+ required for contraction to be stored at total concentrations of up to 20mM, while the free Ca2+ concentration remains at ∼1mM. This storage capacity confers upon muscle the ability to contract frequently with minimal run-down in tension. Calsequestrin is highly acidic, containing up to 50 Ca2+-binding sites, which are formed simply by clustering...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Progress in Biophysics and Molecular Biology
DOI: 10.1016/j.pbiomolbio.2003.07.001


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