CP-225,917 and CP-263,114 Synthesis Support Studies: Testing a Radical Cyclization Strategy for Installation of the Side-Chains
Date
2003
Authors
Banwell, Martin
Coster, Mark
Edwards, Alison
Vogtle, Markus
Journal Title
Journal ISSN
Volume Title
Publisher
CSIRO Publishing
Abstract
The selenocarbonate (18) has been prepared and shown to react with hexabutyldistannane hydride/allyltributylstannane to give, via a radical cyclization/allylation sequence, the lactone (21) embodying vicinal and trans-related functionality likely to be appropriate for elaboration to the side-chains associated with the title compounds (1) and (2) (phomoidrides A and B).
Description
Keywords
Keywords: Free radical reactions; Materials testing; Molecular structure; Negative ions; Stereochemistry; Synthesis (chemical); Allylation sequence; Allyltributylstannane; Hexabutyldistannane hydride; Lactone; Radical cyclization strategy; Selenocarbonate; Side cha
Citation
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Source
Australian Journal of Chemistry
Type
Journal article