Suicide inactivation in adenosylcobalamin-dependent enzymes
Adenosylcobalamin (AdoCbl) dependent enzymes exploit organic radicals for rearrangement of adjacent groups. Their dependence on radicals for catalysis results in the possibility of irreversible inactivation. An allylic analogue of AdoCbl has been synthesized and its corresponding activity assessed with AdoCbl-dependent diol dehydratase (DDH). Suicide inactivation of Ethanolamine ammonia lyase (EAL), an AdoCbl-dependent enzyme that catalyses the irreversible deamination of vicinal amino alcohols...[Show more]
|Collections||ANU Research Publications|
|Source:||Australian Journal of Chemistry|
|01_Sandala_Suicide_inactivation_in_2006.pdf||128.21 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.