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Suicide inactivation in adenosylcobalamin-dependent enzymes

Sandala, Gregory


Adenosylcobalamin (AdoCbl) dependent enzymes exploit organic radicals for rearrangement of adjacent groups. Their dependence on radicals for catalysis results in the possibility of irreversible inactivation. An allylic analogue of AdoCbl has been synthesized and its corresponding activity assessed with AdoCbl-dependent diol dehydratase (DDH). Suicide inactivation of Ethanolamine ammonia lyase (EAL), an AdoCbl-dependent enzyme that catalyses the irreversible deamination of vicinal amino alcohols...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Australian Journal of Chemistry
DOI: 10.1071/CH06052


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