Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

De Rose, Robert; Sullivan, Mark T; Dale, C Jane; Kelleher, Anthony D; Emery, Sean; Cooper, David A.; Ramshaw, Ian; Boyle, David B; Kent, Stephen J

Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

Date

2006

Authors

De Rose, Robert

Sullivan, Mark T

Dale, C Jane

Kelleher, Anthony D

Emery, Sean

Cooper, David A.

Ramshaw, Ian

Boyle, David B

Kent, Stephen J

Publisher

Landes Bioscience

Abstract

Estimating effective doses of novel HIV vaccines is challenging. Dose-response analyses of DNA and fowlpox virus HIV vaccines showed that 1 mg of DNA vaccine and 5 × 107 pfu of fowlpox virus booster was immunogenic in macaques. However, this dose was poo

Keywords

Keywords: DNA vaccine; gamma interferon; Human immunodeficiency virus vaccine; recombinant vaccine; article; cellular immunity; clinical trial; dose response; drug clearance; enzyme immunoassay; enzyme linked immunospot assay; Fowlpox virus; human; immunogenicity; Body surface area; Immunologic dose-response relationship; Prime-boost; Vaccine

URI

http://hdl.handle.net/1885/85199

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ANU Research Publications

Source

Human Vaccines

Type

Journal article

Restricted until

2037-12-31

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Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines: Implications for future trials

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