Characterization of simple sequence repeat variants linked to candidate genes for behavioral phenotypes
Date
2006
Authors
Prichard, Zoe
Easteal, Simon
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Liss Inc
Abstract
Simple sequence repeats (SSRs) have traditionally been used as markers in gene mapping studies and typing for forensic purposes. Recently there has been some speculation that this type of genetic variation also plays a more direct role in influencing gene expression and hence complex phenotypic outcomes such as human behavior. For this reason it is interesting to investigate SSRs linked to candidate genes for various complex phenotypes. An economical multiplex PCR-based assay was designed to simultaneously genotype individuals at 15 loci across 10 candidate genes for human behavioural phenotypes, including seven loci previously unreported in Caucasians (five unreported in any population). All loci were tested for Hardy-Weinberg equilibrium and for two-locus Linkage Disequilibrium. Ewens-Watterson neutrality testing indicated possible selection at a previously unreported DRD2 locus. 2005 Wiley-Liss, Inc.
Description
Keywords
Keywords: adult; allele; article; behavior genetics; exon; gene frequency; genetic variability; genetics; homozygote; human; mutation; nucleotide repeat; phenotype; Adult; Alleles; Exons; Gene Frequency; Genetics, Behavioral; Homozygote; Humans; Mutation; Phenotype
Citation
Collections
Source
Human Mutation
Type
Journal article