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Dendritic synapse location and neocortical spike-timing-dependent plasticity

Froemke, Robert C.; Letzkus, Johannes; Kampa, Bjoern; Hang, Giao B.; Stuart, Gregory J


While it has been appreciated for decades that synapse location in the dendritic tree has a powerful influence on signal processing in neurons, the role of dendritic synapse location on the induction of long-term synaptic plasticity has only recently been explored. Here, we review recent work revealing how learning rules for spike-timing-dependent plasticity (STDP) in cortical neurons vary with the spatial location of synaptic input. A common principle appears to be that proximal synapses show...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Frontiers in Synaptic Neuroscience
DOI: 10.3389/fnsyn.2010.00029


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