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Physiological and pharmacological roles of vascular nucleoside transporters

Li, Rachel; Yang, Cui; Sit Albert, S.M.; Lin, Sophie Y T; Eva Y W , Ho; Leung, George P. H.

Description

Adenosine modulates various vascular functions such as vasodilatation and anti-inflammation. The local concentration of adenosine in the vicinity of adenosine receptors is fine tuned by 2 classes of nucleoside transporters: equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). In vascular smooth muscle cells, 95% of adenosine transport is mediated by ENT-1 and the rest by ENT-2. In endothelial cells, 60%, 10%, and 30% of adenosine transport are mediated...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/84787
Source: Journal of Cardiovascular Pharmacology
DOI: 10.1097/FJC.0b013e31820eb788

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