Physiological and pharmacological roles of vascular nucleoside transporters
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Li, Rachel; Yang, Cui; Sit Albert, S.M.; Lin, Sophie Y T; Eva Y W , Ho; Leung, George P. H.
Description
Adenosine modulates various vascular functions such as vasodilatation and anti-inflammation. The local concentration of adenosine in the vicinity of adenosine receptors is fine tuned by 2 classes of nucleoside transporters: equilibrative nucleoside transporters (ENTs) and concentrative nucleoside transporters (CNTs). In vascular smooth muscle cells, 95% of adenosine transport is mediated by ENT-1 and the rest by ENT-2. In endothelial cells, 60%, 10%, and 30% of adenosine transport are mediated...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/84787 |
Source: | Journal of Cardiovascular Pharmacology |
DOI: | 10.1097/FJC.0b013e31820eb788 |
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