RNAi-based discovery and validation of new drug targets in filarial nematodes
Date
2005
Authors
Behm, Carolyn
Bendig, Mary
McCarter, James
Sluder, Ann
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Publisher
Elsevier
Abstract
Human filarial nematodes cause river blindness and lymphatic filariasis, both of which are diseases that produce considerable morbidity. Control of these diseases relies on drug treatments that are ineffective against macrofilariae and are threatened by the development of resistance. New validated drug targets are required to allow development of new classes of antifilarial drugs. To identify and validate potential new drug targets, we propose a collaborative research strategy utilizing bioinformatic filters and assessment of gene function by RNA interference in Caenorhabditis elegans and Brugia malayi.
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Keywords
Keywords: albendazole; antifilarial agent; antinematodal agent; avermectin; carbamic acid; diethylcarbamazine; imidazole derivative; ivermectin; levamisole; organophosphate; bioinformatics; Brugia malayi; Caenorhabditis elegans; chemotherapy; drug cost; drug effect
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Source
Trends in Parasitology
Type
Journal article
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Restricted until
2037-12-31
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