T Cell determinants incorporating β -amino acid residues are protease resistant and remain immunogenic in vivo
Webb, Andrew; Dunstone, Michelle; Williamson, Nicholas; Price, Jason; de Kauwe, Andrea; Chen, Weisan; Oakley, Aaron; Perlmutter, Patrick; McCluskey, James; Aguilar, Marie-Isabel; Rossjohn, J; Purcell, Anthony
A major hurdle in designing successful epitope-based vaccines resides in the delivery, stability, and immunogenicity of the peptide immunogen. The short-lived nature of unmodified peptide-based vaccines in vivo limits their therapeutic application in the
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|Source:||Journal of Immunology|
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