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Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor

Han, Nian Lin; Clements, John D; Lynch, Joseph


In the ionotropic glutamate receptor, the global conformational changes induced by partial agonists are smaller than those induced by full agonists. However, in the pentameric ligand-gated ion channel receptor family, the structural basis of partial agonism is not understood. This study investigated whether full and partial agonists induce different conformation changes in the glycine receptor chloride channel (GlyR). A substituted cysteine accessibility analysis demonstrated previously that...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M400548200


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