Skip navigation
Skip navigation

Association of PDE11A global haplotype with major depression and antidepressant drug response

Luo, Huai-Rong; Wu, Gui-Sheng; Dong, Chuanhui; Arcos-Burgos, Mauricio (Oscar); Ribeiro, L; Licinio, Julio; Wong, Ma-Li

Description

Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis. There are two PDE genes, PDE11A and PDE1A, located in chromosome...[Show more]

dc.contributor.authorLuo, Huai-Rong
dc.contributor.authorWu, Gui-Sheng
dc.contributor.authorDong, Chuanhui
dc.contributor.authorArcos-Burgos, Mauricio (Oscar)
dc.contributor.authorRibeiro, L
dc.contributor.authorLicinio, Julio
dc.contributor.authorWong, Ma-Li
dc.date.accessioned2015-12-13T22:48:50Z
dc.identifier.issn1176-6328
dc.identifier.urihttp://hdl.handle.net/1885/80247
dc.description.abstractCyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis. There are two PDE genes, PDE11A and PDE1A, located in chromosome 2q31-q32. In this study, we have further explored whether the whole region 2q31-q32 contribute to MDD or antidepressant response 278 depressed Mexican-American participants and 321 matched healthy controls. Although there is no significant interaction between the two genes, the remission rate of individual carrying the combination genotype at rs1880916 (AG/AA) and rs1549870 (GG) is significantly increased. We analyzed the global haplotype by examining 16 single-nucleotide polymorphisms (SNPs) in PDE11A and six SNPs in PDE1A. None of the haplotypes consisting of six SNPs in the PDE1A have a significant difference between depressed and control groups. Among haplotypes consisting of 16 SNPs across 440 kb in the PDE11A gene, 18 common haplotypes (with frequency higher than 0.8%) have been found in the studied population. Six haplotypes showed significantly different frequencies between the MDD group and the control group. The phylogenetic network result for the 16 SNPs showed that several historic recombination events have happened in the PDE11A gene. The frequency of one haplotype is significantly lower in the remitter group than in the nonremitter group for the depressed participants treated with either desipramine or fluoxetine. Thus, our data suggest that the PDE11A global haplotype is associated with both MDD and antidepressant drug response.
dc.publisherDove Medical Press Ltd
dc.sourceNeuropsychiatric Disease and Treatment
dc.subjectKeywords: adenosine; desipramine; fluoxetine; guanosine; phosphodiesterase; phosphodiesterase 11A; phosphodiesterase 1A; unclassified drug; article; chromosome 2q; clinical trial; controlled clinical trial; controlled study; double blind procedure; drug dose escala Antidepressant; Haplotype; Linkage disequilibrium; Major depression; PDE11A; Recombination
dc.titleAssociation of PDE11A global haplotype with major depression and antidepressant drug response
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume5
dc.date.issued2009
local.identifier.absfor110300 - CLINICAL SCIENCES
local.identifier.ariespublicationf5625xPUB8532
local.type.statusPublished Version
local.contributor.affiliationLuo, Huai-Rong, University of Miami Miller School of Medicine
local.contributor.affiliationWu, Gui-Sheng, University of Miami Miller School of Medicine
local.contributor.affiliationDong, Chuanhui, University of Miami Miller School of Medicine
local.contributor.affiliationArcos-Burgos, Mauricio (Oscar), College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRibeiro, L, University of Miami Miller School of Medicine
local.contributor.affiliationLicinio, Julio, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWong, Ma-Li, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage163
local.bibliographicCitation.lastpage170
dc.date.updated2016-02-24T09:42:47Z
local.identifier.scopusID2-s2.0-70449713420
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Luo_Association_of_PDE11A_global_2009.pdf149.4 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  22 January 2019/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator