Luo, Huai-Rong; Wu, Gui-Sheng; Dong, Chuanhui; Arcos-Burgos, Mauricio (Oscar); Ribeiro, L; Licinio, Julio; Wong, Ma-Li
Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual haplotype GAACC in the PDE11A gene was associated with major depressive disorder (MDD) based on block-by-block analysis. There are two PDE genes, PDE11A and PDE1A, located in chromosome...[Show more]
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