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Hypothalamic expression of Eap1 is not directly controlled by ovarian steroids

Matagne, Valerie; Mastronardi, Claudio; Shapiro, Robert A.; Dorsa, Daniel M.; Ojeda, Sergio R


A gene termed EAP1 (enhanced at puberty 1) was recently identified as a transcriptional regulator of female neuroendocrine reproductive function. We have now used in vivo and in vitro assays, and the female rat as an animal model, to determine whether Eap1 gene expression is regulated by ovarian steroids. Eap1 mRNA abundance decreases in both the hypothalamus and cerebral cortex during the infantile-juvenile phases of development, but it increases selectively in the hypothalamus at puberty,...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Endocrinology
DOI: 10.1210/en.2008-0779


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