A methyl transferase links the circadian clock to the regulation of alternative splicing
Sanchez, Sabrina E; Petrillo, Ezequiel; Beckwith, Esteban J.; Zhang, Xu; Rugnone, Matias L.; Hernando, C. Esteban; Cuevas, Juan C.; Godoy Herz, Micaela A.; Depetris-Chauvin, Ana; Simpson, Craig G; Brown, John W S; Borevitz, Justin
Circadian rhythms allow organisms to time biological processes to the most appropriate phases of the dayg-night cycle. Post-transcriptional regulation is emerging as an important component of circadian networks, but the molecular mechanisms linking the circadian clock to the control of RNA processing are largely unknown. Here we show that PROTEIN ARGININE METHYL TRANSFERASE 5 (PRMT5), which transfers methyl groups to arginine residues present in histones and Sm spliceosomal proteins, links the...[Show more]
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