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Synapsin I-associated phosphatidylinositol 3-kinase mediates synaptic vesicle delivery to the readily releasable pool

Cousin, Michael; Malladi, Chandra; Tan, Timothy; Raymond, Clarke; Smillie, Karen; Robinson, Phillip J


Maintaining synaptic transmission requires replenishment of docked synaptic vesicles within the readily releasable pool (RRP) from synaptic vesicle clusters in the synapsin-bound reserve pool. We show that synapsin forms a complex with phosphatidylinositol 3-kinase (PI 3-kinase) in intact nerve terminals and that synapsin-associated kinase activity increases on depolarization. Disruption of either PI 3-kinase activity or its interaction with synapsin inhibited replenishment of the RRP, but did...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M302386200


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