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Presynaptic Ca2+ channels: a functional patchwork

Reid, Christopher M; Bekkers, John; Clements, John D


A key step in the release of neurotransmitter is the entry of Ca 2+ into the presynaptic terminal via voltage-activated Ca 2+ channels. N-type and P/Q-type Ca2+ channels play a predominant role but, surprisingly, their distribution across presynaptic terminals lacks any apparent order. They form a patchwork: at some terminals only N-type channels contribute to transmitter release and in others only P/Q-type channels contribute, but in many terminals both sub-types are active. The physiological...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Trends in Neurosciences
DOI: 10.1016/j.tins.2003.10.003


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