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Osmotic Swelling Activates two Pathways for K + Efflux in a Rat Hepatoma Cell Line

Junankar, Pauline; Karjalainen, Ari; Kirk, Kiaran


The pathways for the efflux of K+ from osmotically-swollen HTC rat hepatoma cells were investigated using 86Rb+ as a tracer for K+. Exposure of HTC cells to a hypotonic solution (< 250 mOsm kg-1) resulted in a transient efflux of 86Rb + that reached a maximal value after ∼1 min, and inactivated within 3 min. This initial 86Rb+ efflux was inhibited by charybdotoxin, clotrimazole and Ba2+, but not by apamin or paxilline, consistent with it being via an intermediate-conductance Ca2+- activated K+...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Cellular Physiology and Biochemistry
DOI: 10.1159/000078106


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