Osmotic Swelling Activates two Pathways for K + Efflux in a Rat Hepatoma Cell Line
The pathways for the efflux of K+ from osmotically-swollen HTC rat hepatoma cells were investigated using 86Rb+ as a tracer for K+. Exposure of HTC cells to a hypotonic solution (< 250 mOsm kg-1) resulted in a transient efflux of 86Rb + that reached a maximal value after ∼1 min, and inactivated within 3 min. This initial 86Rb+ efflux was inhibited by charybdotoxin, clotrimazole and Ba2+, but not by apamin or paxilline, consistent with it being via an intermediate-conductance Ca2+- activated K+...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular Physiology and Biochemistry|
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