Histidine-rich glycoprotein binds to cell-surface heparan sulfate via its N-terminal domain following Zn 2+ chelation
Histidine-rich glycoprotein (HRG) is an α2-glycoprotein found in mammalian plasma at high concentrations (∼150 μg/ml) and is distinguished by its high content of histidine and proline. Structurally, HRG is a modular protein consisting of an N-terminal
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