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Efficacy of DNA and Fowlpox virus priming/boosting vaccines for Simian/Human immunodeficiency virus

Dale, C Jane; De Rose, Robert; Stratov, Ivan; Chea, Socheata; Montefiori, David C; Thomson, Scott; Ramshaw, Ian; Coupar, Barbara E H; Boyle, David B; Law, Matthew G; Kent, Stephen J


Further advances are required in understanding protection from AIDS by T-cell immunity. We analyzed a set of multigenic simian/human immunodeficiency virus (SHIV) DNA and fowlpox virus priming and boosting vaccines for immunogenicity and protective efficacy in outbred pigtail macaques. The number of vaccinations required, the effect of DNA vaccination alone, and the effect of cytokine (gamma interferon) coexpression by the fowlpox virus boost was also studied. A coordinated induction of high...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.78.24.13819-13828.2004


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