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Pharmacological cholesterol lowering reverses fibrotic NASH in obese, diabetic mice with metabolic syndrome

Van Rooyen, Derrick; Gan, Lay; Yeh, Matthew; Haigh, W Geoffrey; Larter, Claire; Ioannou, George; Teoh, Narcissus; Farrell, Geoffrey

Description

Background & Aims We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activate

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/77626
Source: Journal of Hepatology
DOI: 10.1016/j.jhep.2013.02.024

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