Helios marks strongly autoreactive CD4 + T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-KB
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find this discrimination is reported by expression of the transcription factor Helios, which is induced during negative selection but decreases during positive selection. Helios and the proapoptotic protein Bim were coinduced in 55% of nascent CCR7- CD4+ CD69+ thymocytes. These were short-lived cells that up-regulated PD-1 and down-regulated...[Show more]
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|Source:||Journal of Experimental Medicine|
|01_Daley_Helios_marks_strongly_2013.pdf||5.77 MB||Adobe PDF||Request a copy|
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