Daley, Stephen; Hu, Daniel; Goodnow, Christopher
Acquisition of self-tolerance in the thymus requires T cells to discriminate strong versus weak T cell receptor binding by self-peptide-MHC complexes. We find this discrimination is reported by expression of the transcription factor Helios, which is induced during negative selection but decreases during positive selection. Helios and the proapoptotic protein Bim were coinduced in 55% of nascent CCR7- CD4+ CD69+ thymocytes. These were short-lived cells that up-regulated PD-1 and down-regulated...[Show more]
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