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Extent of systemic spread determines CD8+ T cell immunodominance for laboratory strains, smallpox vaccines, and zoonotic isolates of vaccinia virus

Flesch, Inge; Hollett (previously Noel), Natasha; Wong, Yik Chun; Quinan, Barbara; Howard, Debbie; da Fonseca, Flavio G.; Tscharke, David

Description

CD8+ T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary greatly in immunogenicity, allowing them to be ranked in an immunodominance hierarchy. However, the

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
URI: http://hdl.handle.net/1885/76906
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1402508

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