Extent of systemic spread determines CD8+ T cell immunodominance for laboratory strains, smallpox vaccines, and zoonotic isolates of vaccinia virus
Date
2015
Authors
Flesch, Inge
Hollett (previously Noel), Natasha
Wong, Yik Chun
Quinan, Barbara
Howard, Debbie
da Fonseca, Flavio G.
Tscharke, David
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American Association of Immunologists
Abstract
CD8+ T cells that recognize virus-derived peptides presented on MHC class I are vital antiviral effectors. Such peptides presented by any given virus vary greatly in immunogenicity, allowing them to be ranked in an immunodominance hierarchy. However, the
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Journal of Immunology
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Journal article
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2037-12-31
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