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Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling

Prakash, Monica; Munoz, Marcia; Jain, Rohit; Tong, Philip; Koskinen, Aulikki; Regner, Matthias; Kleifeld, Oded; Ho, Bosco; Olson, Matthew; Turner, Stephen; Mrass, Paulus; Weninger, Wolfgang; Bird, Phillip I


Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the interplay between cytotoxic lymphocytes and their environment. Here, we show that GzmB-null effector Tcells and natural killer (NK) cells exhibited a cell-autonomous homing deficit in mouse models of inflammation and Ectromelia virus infection. Intravital...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Immunity
DOI: 10.1016/j.immuni.2014.11.012


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