Skip navigation
Skip navigation

Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling

Prakash, Monica; Munoz, Marcia; Jain, Rohit; Tong, Philip; Koskinen, Aulikki; Regner, Matthias; Kleifeld, Oded; Ho, Bosco; Olson, Matthew; Turner, Stephen; Mrass, Paulus; Weninger, Wolfgang; Bird, Phillip I

Description

Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the interplay between cytotoxic lymphocytes and their environment. Here, we show that GzmB-null effector Tcells and natural killer (NK) cells exhibited a cell-autonomous homing deficit in mouse models of inflammation and Ectromelia virus infection. Intravital...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/76314
Source: Immunity
DOI: 10.1016/j.immuni.2014.11.012

Download

File Description SizeFormat Image
01_Prakash_Granzyme_B_promotes_cytotoxic_2014.pdf3.47 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator