Troeberg, Linda; Lazenbatt, Christopher; Anower-E-Khuda, Md. Ferdous; Freeman, Craig; Federov, Oleg; Habuchi, Hiroko; Habuchi, Osami; Kimata, Koji; Nagase, Hideaki
Summary Tissue inhibitor of metalloproteinase 3 (TIMP-3) is an important regulator of extracellular matrix (ECM) turnover. TIMP-3 binds to sulfated ECM glycosaminoglycans or is endocytosed by cells via low-density lipoprotein receptor-related protein 1 (LRP-1). Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1. HS and CSE also increased TIMP-3 affinity for glycan-binding...[Show more]
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