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Characterization of Barmah Forest virus pathogenesis in a mouse model

Herrero, Lara; Lidbury, Brett; Bettadapura, Jayaram; Peng, Jian; Herrig, Belinda L; Hey-Cunningham, William J.; Sheng, Kuo-Ching; Zakhary, Andrew; Mahalingam, Suresh

Description

Alphaviruses including Barmah Forest virus (BFV) and Ross River virus (RRV) cause arthritis, arthralgia and myalgia in humans. The rheumatic symptoms in human BFV infection are very similar to those of RRV. Although RRV disease has been studied extensively, little is known about the pathogenesis of BFV infection. We sought to establish a mouse model for BFV to facilitate our understanding of BFV infectivity, tropism and pathogenesis, and to identify key pathological and immunological mechanisms...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/75454
Source: Journal of General Virology
DOI: 10.1099/vir.0.064733-0

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