Smchd1 regulates a subset of autosomal genes subject to monoallelic expression in addition to being critical for X inactivation
Date
2013
Authors
Mould, Arne
Pang, Zhenyi
Pakusch, Miha
Tonks, Ian D.
Stark, Mitchell
Carrie, Dianne
Mukhopadhyay, Pamela
Seidel, Annica
Ellis, Jonathan J.
Deakin, Janine
Journal Title
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Volume Title
Publisher
BioMed Central Ltd.
Abstract
Background: Smchd1 is an epigenetic modifier essential for X chromosome inactivation: female embryos lacking Smchd1 fail during midgestational development. Male mice are less affected by Smchd1-loss, with some (but not all) surviving to become fertile adu
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Keywords
Keywords: cadherin; cell protein; protocadherin alpha; protocadherin beta; protocadherin gamma; Smchd1 protein; unclassified drug; article; autosomal disorder; biallelic expression; chromosome; CpG island; embryo development; epigenetics; gene cluster; gene disrupt Clustered protocadherins; Genomic imprinting; Monoallelic expression; Smchd1; X inactivation
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Source
Epigenetics and Chromatin
Type
Journal article
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Restricted until
2037-12-31
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