The role of ring D in the antitumor antibiotic streptonigrin: metal complexation, DNA binding and topoisomerase inhibition by ABC ring analogues of streptonigrin
Date
2001
Authors
Anderberg, Pia I
Harding, Margaret
Journal Title
Journal ISSN
Volume Title
Publisher
Cognizant Communication Corporation
Abstract
The interaction of 7-amino-2-(6′-carboxy-2′-pyridyl)-6-methoxy-5,8-quinolinedione, an ABC ring analogue of the antitumour antibiotic streptonigrin, with zinc(II), oligonucleotides and DNA in the presence of zinc(II), and on the relaxation of DNA by to
Description
Keywords
Keywords: 7 amino 2 (6' carboxy 2' pyridyl) 6 methoxy 5,8 quinolinedione; DNA; DNA topoisomerase; DNA topoisomerase (ATP hydrolysing); phenol derivative; rufocromomycin; unclassified drug; zinc derivative; aqueous solution; article; chemical interaction; complex fo Amhloquinone; Anticancer; Bipyridyl; Drug-DNA complex; Streptonigrin; Topoisomerase
Citation
Collections
Source
Anti-Cancer Drug Design
Type
Journal article