Antitumor metallocenes: structure-activity studies and interactions with biomolecules
The metallocene dihalides are a relatively new class of small, hydrophobic organometallic anticancer agents that exhibit antitumour properties against numerous cell lines including leukemias P388 and L1210, colon 38 and Lewis lung carcinomas, B16 melanoma, solid and fluid Ehrlich ascites tumours and several human colon and lung carcinomas transplanted into athymic mice. Titanocene dichloride I has been the most widely studied metallocene and the drug is currently in phase II clinical trials....[Show more]
|Collections||ANU Research Publications|
|Source:||Current Medicinal Chemistry|
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