The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells
Date
2013
Authors
Gatto, Dominique
Wood, Katherine
Caminschi, Irina
Murphy-Durland, Danielle
Schofield, Peter
Christ, Daniel
Karupiah, Gunasegaran
Brink, Robert
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Volume Title
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Nature Publishing Group
Abstract
Spleen-resident dendritic cell (DC) populations occupy sentinel positions for the capture and presentation of blood-borne antigens. Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regu
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Keywords
Keywords: CD4 antigen; G protein coupled receptor; ligand; protein EBI2; unclassified drug; animal cell; animal tissue; article; CD4+ T lymphocyte; cell function; cell migration; cell subpopulation; cell survival; chemotaxis; controlled study; dendritic cell; homeo
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Nature Immunology
Type
Journal article
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Restricted until
2037-12-31
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