Kuo, Ivana; Howitt, Lauren; Sandow, Shaun, L; McFarlane, Alexandra; Hansen, Pernille; Hill, Caryl
Low-voltage-activated T-type calcium channels play an important role in regulating cellular excitability and are implicated in conditions, such as epilepsy and neuropathic pain. T-type channels, especially Cav3.1 and Cav3.2, are also expressed in the vasculature, although patch clamp studies of isolated vascular smooth muscle cells have in general failed to demonstrate these low-voltage-activated calcium currents. By contrast, the channels which are blocked by T-type channel antagonists are...[Show more]
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