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Binding of hanatoxin to the voltage sensor of Kv2.1

Chen, Rong; Robinson, Anna; Chung, Shin-Ho


Hanatoxin 1 (HaTx1) is a polypeptide toxin isolated from spider venoms. HaTx1 inhibits the voltage-gated potassium channel kv2.1 potently with nanomolar affinities. Its receptor site has been shown to contain the S3b-S4a paddle of the voltage sensor (VS). Here, the binding of HaTx1 to the VSs of human Kv2.1 in the open and resting states are examined using a molecular docking method and molecular dynamics. Molecular docking calculations predict two distinct binding modes for the VS in the...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Toxins
DOI: 10.3390/toxins4121552
Access Rights: Open Access


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