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Short-term plasticity of gray matter associated with leptin deficiency and replacement

London, Edythe D.; Berman, S M; Chakrapani, Shruthi; Delibasi, Tuncay; Monterosso, John; Erol, Halil Kutlu; Da Paz Filho, Gilberto; Wong, Ma-Li; Licinio, Julio

Description

Context: Leptin affects neurogenesis, neuronal growth, and viability. We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake. Objective: The aim of this study was to report the changes in brain structure at different states of leptin supplementation. Design: We conducted a nonrandomized trial. Setting and Patients: We studied three...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/70488
Source: Journal of Clinical Endocrinology and Metabolism
DOI: 10.1210/jc.2011-0314

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