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Promiscuity comes at a price: Catalytic versatility vs efficiency in different metal ion derivatives of the potential bioremediator GpdQ

Daumann, Lena J; McCarthy, Bianca Y; Hadler, Kieran S; Murray, Tracy; Gahan, Lawrence; Larrabee, James A; Ollis, David; Schenk, Gerhard

Description

The glycerophosphodiesterase from Enterobacter aerogenes (GpdQ) is a highly promiscuous dinuclear metallohydrolase with respect to both substrate specificity and metal ion composition. While this promiscuity may adversely affect the enzyme's catalytic efficiency its ability to hydrolyse some organophosphates (OPs) and by-products of OP degradation have turned GpdQ into a promising candidate for bioremedial applications. Here, we investigated both metal ion binding and the effect of the metal...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/69862
Source: Biochimica et Biophysica Acta: Proteins & Proteomics
DOI: 10.1016/j.bbapap.2012.02.004

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