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Altered gap junctional communication and renal haemodynamics in Zucker fatty rat model of type 2 diabetes

Takenaka, T; Inoue, T; Okada, H; Ohno, Y; Miyazaki, T; Chaston, Daniel; Hill, Caryl; Suzuki, H

Description

Aims/hypothesis: We examined the link between altered gap junctional communication and renal haemodynamic abnormalities in diabetes in studies performed on Zucker lean (ZL) and the Zucker diabetic fatty (ZDF) rat model of type 2 diabetes. Methods: The abundance of connexin (Cx) 37, 40 and 43 was assessed by western blot and immunohistochemistry. Renal haemodynamics was characterised with GAP peptides, which are Cx mimetics, to inhibit gap junctions as a probe in both strains. Results: ZDF rats...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/69344
Source: Diabetologia
DOI: 10.1007/s00125-011-2175-8

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