Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine
Chen, Jinbiao; Liu, Mary Y; Parish, Christopher; Chong, Beng; Khachigian, Levon M
Description
A three amino acid sequence, Ser/Thr-Pro-Ser/Thr, was recently identified and characterized as a novel nuclear localization signal (Chuderland et al., 2008). The immediate-early gene product, early growth response-1 is a three zinc finger containing transcription factor implicated in a wide variety of pathologies, and has a bipartite nuclear localization domain identified two decades ago. Efficient nuclear localization of Egr-1 is vital to its function as a transcription factor. Interestingly,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/69165 |
Source: | The International Journal of Biochemistry and Cell Biology |
DOI: | 10.1016/j.biocel.2011.03.004 |
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