Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine
A three amino acid sequence, Ser/Thr-Pro-Ser/Thr, was recently identified and characterized as a novel nuclear localization signal (Chuderland et al., 2008). The immediate-early gene product, early growth response-1 is a three zinc finger containing transcription factor implicated in a wide variety of pathologies, and has a bipartite nuclear localization domain identified two decades ago. Efficient nuclear localization of Egr-1 is vital to its function as a transcription factor. Interestingly,...[Show more]
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|Source:||The International Journal of Biochemistry and Cell Biology|
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