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Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine

Chen, Jinbiao; Liu, Mary Y; Chong, Beng; Khachigian, Levon M; Parish, Christopher


A three amino acid sequence, Ser/Thr-Pro-Ser/Thr, was recently identified and characterized as a novel nuclear localization signal (Chuderland et al., 2008). The immediate-early gene product, early growth response-1 is a three zinc finger containing transcription factor implicated in a wide variety of pathologies, and has a bipartite nuclear localization domain identified two decades ago. Efficient nuclear localization of Egr-1 is vital to its function as a transcription factor. Interestingly,...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2011.03.004


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