Role of novel type i interferon epsilon in viral infection and mucosal immunity
Intranasal infection with vaccinia virus co-expressing interferon epsilon (VV-HIV-IFN-) was used to evaluate the role of IFN-in mucosal immunity. VV-HIV-IFN-infection induced a rapid VV clearance in lung that correlated with (i) an elevated lung VV-specific CD8+ CD107a+ IFN-γ+ population expressing activation markers CD69/CD103, (ii) enhanced lymphocyte recruitment to lung alveoli with reduced inflammation, and (iii) an heightened functional/cytotoxic CD8+ CD4+ T-cell subset (CD3 hi CCR7 hi...[Show more]
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