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Molecular pathways involved in crosstalk between cancer cells, osteoblasts and osteoclasts in the invasion of bone by oral squamous cell carcinoma

Quan, Jingjing; Zhou, Chuanxiang; Newell, W. Johnson; Francis, Glenn; Gao, Jin; Dahlstrom, Jane


Aims: This study investigates whether matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, interacting with other molecules important in osteoblast differentiation and osteoclastogenesis, could play important roles in the invasion of bone by oral squamous cell carcinoma (OSCC). Methods: Supernatant (conditioned medium, CM) was collected from OSCC cell lines (SCC15 and SCC25), and from cultured osteoblasts (hFOB cell line and a primary culture, OB), and used for indirect co-culture:...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Pathology
DOI: 10.1097/PAT.0b013e3283513f3b


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