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Binding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels

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Chen, Rong; Chung, Shin-Ho

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Scorpion α-toxins bind to the voltage-sensing domains of voltage-gated sodium (NaV) channels and interfere with the inactivation mechanisms. The functional surface of α-toxins has been shown to contain an NC-domain consisting of the five-residue turn (p

dc.contributor.authorChen, Rong
dc.contributor.authorChung, Shin-Ho
dc.date.accessioned2015-12-10T23:24:24Z
dc.identifier.issn0006-2960
dc.identifier.urihttp://hdl.handle.net/1885/67169
dc.description.abstractScorpion α-toxins bind to the voltage-sensing domains of voltage-gated sodium (NaV) channels and interfere with the inactivation mechanisms. The functional surface of α-toxins has been shown to contain an NC-domain consisting of the five-residue turn (p
dc.publisherAmerican Chemical Society
dc.sourceBiochemistry
dc.subjectKeywords: Atomistic molecular dynamics simulations; Binding modes; Binding pockets; C-terminus; Dissociation constant; Extracellular; Functional surfaces; Hydrophobic clusters; Inactivation mechanisms; Molecular dynamics simulations; Salt bridges; Sodium channel; B
dc.titleBinding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume51
dc.date.issued2012
local.identifier.absfor030100 - ANALYTICAL CHEMISTRY
local.identifier.ariespublicationf5625xPUB1410
local.type.statusPublished Version
local.contributor.affiliationChen, Rong, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChung, Shin-Ho, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue39
local.bibliographicCitation.startpage7775
local.bibliographicCitation.lastpage7782
local.identifier.doi10.1021/bi300776g
dc.date.updated2016-02-24T08:46:17Z
local.identifier.scopusID2-s2.0-84867093419
local.identifier.thomsonID000309320300013
CollectionsANU Research Publications

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