Binding modes and functional surface of anti-mammalian scorpion α-toxins to sodium channels
Date
2012
Authors
Chen, Rong
Chung, Shin-Ho
Journal Title
Journal ISSN
Volume Title
Publisher
American Chemical Society
Abstract
Scorpion α-toxins bind to the voltage-sensing domains of voltage-gated sodium (NaV) channels and interfere with the inactivation mechanisms. The functional surface of α-toxins has been shown to contain an NC-domain consisting of the five-residue turn (p
Description
Keywords
Keywords: Atomistic molecular dynamics simulations; Binding modes; Binding pockets; C-terminus; Dissociation constant; Extracellular; Functional surfaces; Hydrophobic clusters; Inactivation mechanisms; Molecular dynamics simulations; Salt bridges; Sodium channel; B
Citation
Collections
Source
Biochemistry
Type
Journal article
Book Title
Entity type
Access Statement
License Rights
Restricted until
2037-12-31
Downloads
File
Description