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Cancer tumors as Metazoa 1.0: Tapping genes of ancient ancestors

Davies, Paul; Lineweaver, Charles


The genes of cellular cooperation that evolved with multicellularity about a billion years ago are the same genes that malfunction to cause cancer. We hypothesize that cancer is an atavistic condition that occurs when genetic or epigenetic malfunction unlocks an ancient 'toolkit' of pre-existing adaptations, re-establishing the dominance of an earlier layer of genes that controlled loose-knit colonies of only partially differentiated cells, similar to tumors. The existence of such a toolkit...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Physical Biology
DOI: 10.1088/1478-3975/8/1/015001


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