Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort
Date
2011
Authors
Beckmann, Kerri
Buckingham, John
Craft, Paul
Zhang, Y
Roder, David
Stuart-Harris, Robin
Dahlstrom, Jane
Journal Title
Journal ISSN
Volume Title
Publisher
Churchill Livingstone
Abstract
Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.
Description
Keywords
Keywords: adult; article; Australia; bilateral cancer; breast cancer; cancer grading; cancer hormone therapy; cancer radiotherapy; cancer risk; cancer survival; controlled study; disease free survival; family history; female; high risk patient; human; intermethod c Bilateral; Breast neoplasm; Epidemiology; Survival
Citation
Collections
Source
The Breast
Type
Journal article
Book Title
Entity type
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2037-12-31