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The effects of Castanospermine, an oligosaccharide processing inhibitor, on mononuclear/endothelial cell binding and the expression of cell adhesion molecules

Hibberd, Adrian D.; Trevillian, Paul R; Clark, David A.; McElDuff, Patrick; Cowden, William


Introduction: In this study we aimed to determine whether Castanospermine, a transplant immunosuppressive agent, impaired mononuclear/endothelial cell binding and expression of their cell adhesion molecules. Methods: The binding of human umbilical vein endothelial cells with peripheral blood mononuclear cells was measured by a binding assay using Chromium 51 label; the membrane expression of cell adhesion molecules was measured by flow cytometry expressed as mean fluorescence intensity ratios....[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Transplant Immunology
DOI: 10.1016/j.trim.2012.05.002


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