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Inhibition of colon cancer metastasis by a 3-end antisense urokinase receptor mRNA in a nude mouse model

Wang, Yang; Liang, X; Wu, Shanshan; Murrell, George A C; Doe, W


The role of urokinase-type plasminogen activator receptor (uPAR) in human colon cancer metastasis has not been tested using an antisense approach. In our study, the HCT116 cells, with high metastatic potential were transfected with expression vectors containing a 3′ or 5′ uPAR cDNA fragment in an antisense (AS) orientation. Transfection of 4 clones was confirmed by DNA hybridization analysis. Receptor-bound endogenous uPA activities of the clones were reduced to 16-68% of controls. The...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: International Journal of Cancer
DOI: 10.1002/1097-0215(200102)9999:9999<::AID-IJC1178>3.0.CO;2-6


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