A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation
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Al Nadaf, Shafagh; Deakin, Janine; Gilbert, Clement; Robinson, Terence J; Graves, Jennifer; Waters, Paul
Description
Sex chromosome dosage compensation in both eutherian and marsupial mammals is achieved by X chromosome inactivation (XCI) - transcriptional repression that silences one of the two X chromosomes in the somatic cells of females. We recently used RNA fluorescent in situ hybridization (FISH) to show, in individual nuclei, that marsupial X inactivation (in the absence of XIST) occurs on a gene-by-gene basis, and that escape from inactivation is stochastic and independent of gene location. In the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/64030 |
Source: | Chromosoma |
DOI: | 10.1007/s00412-011-0343-8 |
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01_Al Nadaf_A_cross-species_comparison_of_2012.pdf | 288.23 kB | Adobe PDF | Request a copy | |
02_Al Nadaf_A_cross-species_comparison_of_2012.pdf | 280.44 kB | Adobe PDF | Request a copy |
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